A provocative new study reveals the complex effects of the space environment on human health, providing insight into potential damage to blood, cell structure and the immune system. The study focused on SpaceX's Inspiration4 mission, which successfully sent two men and two women into space in 2021 to orbit the Earth for three days and shed some light on the effects of space travel on the human body. The research data, derived directly from the Inspiration4 mission, shows that even a brief trip to space can significantly damage the human immune system, trigger an inflammatory response, and profoundly affect cell structure. In particular, space travel triggered unprecedented changes in cytokines that play a key role in immune response and muscle regulation but are not usually directly associated with inflammation. In particular, the study found a significant increase in muscle factors, which are physiological responses specific to skeletal muscle cells in microgravity, rather than a simple immune response. Although non-muscular tissues did not show changes in proteins associated with inflammation, specific leg muscles such as soleus and tibialis anterior muscles showed significant signs of metabolic activity, especially increased interleukin in the latter, further enhancing the activation of immune cells.

LONDON, July 9 (Reuters) - U.S.-based hedge fund Elliott Associates on Tuesday urged a London court to overturn a verdict supporting the London Metal Exchange's (LME) cancellation of nickel trades partly because the exchange failed to disclose documents. The LME annulled $12 billion in nickel trades in March 2022 when prices shot to records above $100,000 a metric ton in a few hours of chaotic trade. Elliott and market maker Jane Street Global Trading brought a case demanding a combined $472 million in compensation, alleging at a trial in June last year that the 146-year-old exchange had acted unlawfully. London's High Court ruled last November that the LME had the right to cancel the trades because of exceptional circumstances, and was not obligated to consult market players prior to its decision. Lawyers for Elliott told London's Court of Appeal that the LME belatedly released documents in May detailing its "Kill Switch" and "Trade Halt" internal procedures. It also newly disclosed an internal report that Elliott said detailed potential conflicts of interest at the exchange. "It was troubling that one gets disclosure out of the blue in the Court of Appeal for the first time," Elliott lawyer Monica Carss-Frisk told the court. Jane Street Global did not appeal the ruling. "If we had had them (documents) in the proceedings before the divisional court, we may well have sought permission to cross examine." LME lawyers said the new documents were not relevant. "The disclosed documents do not affect the reasoning of the divisional court or the merits of the arguments on appeal," the exchange said in documents prepared for the appeal hearing. "Elliott's appeal is largely a repetition of the arguments which were advanced, and rightly rejected." The LME said it had both the power and a duty to unwind the trades because a record $20 billion in margin calls could have led to at least seven clearing members defaulting, systemic risk and a potential "death spiral". Elliott said the ruling diluted protection provided by the Human Rights Act and also wrongly concluded the LME had the power to cancel the trades.

JOHANNESBURG, July 9 (Reuters) - The South African rand was little changed in early trade on Tuesday, as markets awaited the Federal Reserve chair's testimony in Washington and U.S. June inflation data for clues on the country's future interest rate path. At 0644 GMT, the rand traded at 18.1300 against the dollar , near its previous close of 18.1175. "The rand has opened marginally softer at 18.13 this morning, and we expect trading to remain range-bound in the short term," said Andre Cilliers, currency strategist at TreasuryONE. Markets will listen to the tone of Fed Chair Jerome Powell's testimony in Washington on Tuesday and Wednesday and look to June inflation data out of the U.S. later this week for hints on the future interest rate path in the world's biggest economy. "Analysts will be gauging the Fed's response to the recent softer U.S. economic and labour data, with markets already starting to price in two rate cuts this year," Cilliers added. The risk-sensitive rand often takes cues from global drivers like U.S. economic policy in the absence of major local factors. South Africa's benchmark 2030 government bond was slightly stronger in early deals, with the yield down 1 basis point at 9.74%.

Editor's Note: This year marks the 10th anniversary of the Belt and Road Initiative (BRI) proposed by Chinese President Xi Jinping. Through the lens of foreign pundits, we take a look at 10 years of the BRI - how it achieves win-win cooperation between China and participating countries of the BRI and how it has given the people of these countries a sense of fulfillment. In an interview with Global Times (GT) reporter Li Aixin, Erik Solheim (Solheim), former under-secretary-general of the United Nations and former executive director of the UN Environment Programme, recalled how the BRI helped shorten a previously long journey in Sri Lanka to a half-hour trip. "We will all be losers in a de-globalized, de-coupled world. The BRI can play a key role in bringing the world together," Solheim said. This is the 18th piece of the series. GT: How do you evaluate the role of the BRI in promoting development in participating countries over the past 10 years? Solheim: The BRI has been a major driver of development since it was announced by President Xi Jinping in Kazakhstan 10 years ago. The China-Laos Railway has connected landlocked Laos to the Chinese and European rail network, making it possible for Laos to sell more goods and welcome more tourists. Rail corridors in Kenya and from Djibouti to Addis Ababa connect the interior of Africa to the coast, bringing opportunities for much faster development in East Africa. The Bandung-Jakarta railway in Indonesia, Hanoi metro, roads and ports in Sri Lanka - there are great examples of good south-south and BRI projects in almost every corner of the world. GT: In your experience of traveling around the world, has any BRI-related story left a deep impression on you? Solheim: Yes, many! I'll just mention two. When I was chief negotiator in the Sri Lanka peace process 15 years ago, it took a long time to travel from the airport to Colombo, the capital of Sri Lanka. When I came back last year, it took half an hour on wonderful Chinese-built highways. Traveling through Mombasa, a coastal city in Kenya, you see a lot of poverty and run down houses. Then all of a sudden, a green, clean, well-run oasis opens up. It's the end station of the Nairobi-Mombasa railway which links the capital Nairobi to the coast. The rail station stands out and is showing the future for Kenya. GT: The EU proposed the Global Gateway, and the US proposed the Build Back Better World. What do you think are the similarities and differences between these projects and the BRI? Solheim: I really wish success for the Western initiatives. What developing nations ask for is a choice of good cooperation with both China and the West. Unfortunately, up to now, a number of the Western-led initiatives have been more like media events. They lack structure, secretariat, finances and clear direction. Nearly all nations in the world want to see close people-to-people relations, investment and political cooperation with both China and the West. No one wants to choose. GT: Some people from the West are talking about "de-coupling" and "de-risking." Both seem to be another way of saying "de-globalization." Do you think "de-coupling" and "de-risking" will affect the BRI? And what role will the BRI play in maintaining globalization? Solheim: Decoupling is probably the most unwise idea in the world today. It's outright dangerous. Facing climate change, environmental degradation, economic troubles, war in Ukraine and other places, and the threat of pandemics, we need more, not less, cooperation. We will all be losers in a de-globalized, de-coupled world. The BRI can play a key role in bringing the world together. Almost all developing countries have made BRI agreements with China. As an example, when President Xi met all the leaders of Central Asia recently in Xi'an, Northwest China's Shaanxi Province, they made a very ambitious declaration on future green cooperation between China and Central Asia. GT: You have previously said that the BRI is a fantastic vehicle to promote green global development, which can boost the economy and ecology at the same time. Could you elaborate on how you think the BRI has achieved development of the economy and ecology? Solheim: In the beginning there were too many fossil fuel projects among BRI programs. In the BRI International Green Development Coalition, we argued this should stop. When President Xi pledged to stop building new coal-fired power projects overseas, it was one of the most important environmental decisions ever. Also, it happened at a time when important BRI nations like Bangladesh, Kenya and Pakistan decided they could grow their economies and go green without coal. The BRI will in the next decade become the world's most important vehicle for green energy and green transport. We will see massive investments in solar and wind power, hydrogen, electric batteries and more. GT: How do you view China's goal of achieving harmony between humanity and nature in modernization? In what way is China's story in pursuing harmony between humanity and nature relevant to other countries? Solheim: China now covers between 60 percent and 80 percent of all major green technologies in the world - solar, wind, hydro, batteries, electric cars and high-speed rail. Companies like Longi, BYD and CATL are the world leaders in their sectors. More remarkably and maybe less noticed abroad, China is also a global leader in protecting nature. It's embarking upon one of the most massive national park programs, with a focus on Qinghai Province and Xizang Autonomous Region. China is by far the biggest tree planter in the world and the global leader in desert control in Kubuqi, Inner Mongolia and other places. China has been hugely successful in the recovery of endangered species like the Giant Panda, Tibetan Antelope and Snow Leopard. A new center for mangrove restoration is being set up in Shenzhen and the fishing ban in the Yangtze will restore that magnificent ecosystem. The Belt and Road is a great opportunity for the world to learn from good Chinese green practices.

AIRO, July 8 (Reuters) - A new Israeli assault on Gaza on Monday threatened ceasefire talks at a crucial moment, the head of Hamas said, as Israeli tanks pressed into the heart of Gaza City and ordered residents out after a night of massive bombardment. Residents said the airstrikes and artillery barrages were among the heaviest in nine months of conflict between Israeli forces and Hamas militants in the enclave. Thousands fled. The assault unfolded as senior U.S. officials were in the region pushing for a ceasefire after Hamas made major concessions last week. The militant group said the new offensive appeared intended to derail the talks and called for mediators to rein in Israel's Prime Minister Benjamin Netanyahu. The assault "could bring the negotiation process back to square one. Netanyahu and his army will bear full responsibility for the collapse of this path," Hamas quoted leader Ismail Haniyeh as saying. Gaza City, in the north of the Palestinian enclave, was one of Israel's first targets at the start of the war in October. But clashes with militants there have persisted and civilians have sought shelter elsewhere, adding to waves of displacement. Much of the city lies in ruins. Residents said Gaza City neighbourhoods were bombed through the night into the early morning hours of Monday. Several multi-storey buildings were destroyed, they said. The Gaza Civil Emergency Service said it believed dozens of people were killed but emergency teams were unable to reach them because of ongoing offensives. Gaza residents said tanks advanced from at least three directions on Monday and reached the heart of Gaza City, backed by heavy Israeli fire from the air and ground. That forced thousands of people out of their homes to look for safer shelter, which for many was impossible to find, and some slept on the roadside.