A provocative new study reveals the complex effects of the space environment on human health, providing insight into potential damage to blood, cell structure and the immune system. The study focused on SpaceX's Inspiration4 mission, which successfully sent two men and two women into space in 2021 to orbit the Earth for three days and shed some light on the effects of space travel on the human body. The research data, derived directly from the Inspiration4 mission, shows that even a brief trip to space can significantly damage the human immune system, trigger an inflammatory response, and profoundly affect cell structure. In particular, space travel triggered unprecedented changes in cytokines that play a key role in immune response and muscle regulation but are not usually directly associated with inflammation. In particular, the study found a significant increase in muscle factors, which are physiological responses specific to skeletal muscle cells in microgravity, rather than a simple immune response. Although non-muscular tissues did not show changes in proteins associated with inflammation, specific leg muscles such as soleus and tibialis anterior muscles showed significant signs of metabolic activity, especially increased interleukin in the latter, further enhancing the activation of immune cells.

A Portadown man has avoided jail after sexually assaulting a 16-year-old shop worker under his employment. -ADVERTISEMENT- Brian Thomas Chapman (58), of Moyallan Road, appeared before Newry Magistrates’ Court on Monday for sentencing on two counts of sexual assault. The prosecution outlined that on September 23, 2020, a 16-year-old student in the employment of Brian Chapman, disclosed to her mother about incidents that had occurred in her workplace. She said Chapman had put his hand on her thigh and the back of her leg. She also disclosed that she had been getting extra money from him and he had been sending her text messages. The allegations were reported to police the next day, September 24. The victim then took part in an interview on October 9, in which she said, when she was alone in Chapman’s office, he placed his hand on her upper thigh and his other hand on her lower back, underneath her trousers. The defendant was arrested and interviewed at Lurgan police station, where he denied the allegations. His phone was seized and an examination was carried out. The first interview of the defendant took place on October 9, during which he admitted to sending a message about wanting the victim to work 24/7, but stated this was a joke. The second interview took place on January 28, 2021, where he admitted to sending the 24/7 message, but denied sending other messages, such as “hope you’re spending the pounds on something special”. Throughout this process, Chapman denied sending the messages and denied any of the sexual assaults alleged by the victim. On the Chapman’s criminal record, the prosecution added that he was convicted of three common assaults on appeal. In terms of commission, these matters pre-dated this case but the conviction occurred during the running of this case and also involved a female working for the defendant. Prosecution continued that the age of the victim was an aggravating feature, arguing there was a “vulnerability” due to the “power-imbalance” between Chapman and the young student working for him. An additional aggravating feature, they said, was that during the course of the defence, part of the defence was that the victim had “manipulated or manufactured” some of the text messages that were sent. A defence lawyer, speaking on the pre-sentence report, noted the author deemed Chapman to be of low risk. He also noted that similar offences were contested in the County Court in respect of another complaint, with the judge substituting indecent assault charges for common assault. He also argued a Sexual Offences Prevention Order (SOPO) was not necessary as the offending was four years ago, there has been no repetition and risk had been addressed. District Judge Eamonn King noted the defendant was convicted on two of four original charges following a contest, which ran over a number of days, with the case adjourned for a pre-sentence report and victim impact statement to be produced. He added the defendant “continues to deny” the charges and seeks to appeal the outcome. District Judge King, on reading the pre-sentence report, noted the defendant “denies ever hugging or touching the individual and he denies any sexual attraction to the victim”, but pointed to a paragraph in the report which stated, “From the available evidence, it’s possible to surmise that he demonstrated risk taking and impulsive behaviour. It appears that he took advantage of his position and power in a bid to meet his sexual needs, given the victim’s young age and the fact that he was her employer”. The report added that this demonstrated “limited victim empathy and responsibility due to his denial of the offences”. On the victim impact statement, District Judge King described her as a young girl getting her first job, with the “world as her oyster”. He continued: “As a result of what she says occurred, that turned on its head. It left her feeling inwardly uncomfortable, anxious and lonely. She cut herself off from her friends. She stopped going out. She didn’t want to go to school.” He also described a “degree of manipulation” in the case, as this was the victim’s first job and there was a power imbalance between her as an employee, and Chapman as the employer. In his sentencing remarks, District Judge King, said: “I’ve taken time to emphasise to the victim in this case that the victim did nothing wrong. The victim did everything right and the victim shouldn’t feel lonely, anxious or isolated. “The victim should feel confident, strong and outgoing.” Owing to the defendant’s ongoing denial of the charges, he added: “My sentencing exercise isn’t the conclusion of the case today, but I will sentence, so that we can move towards the conclusion going forward. “I am satisfied, irrespective of what the pre-sentence report says, that the defendant took advantage of someone, attempted to groom someone and was guilty of the two offences.” On the two counts, Chapman was sentenced to three months in prison, suspended for two years. He was also made subject to a Sexual Offences Prevention Order (SOPO) for five years and placed on the sex offenders’ register for seven years. Following sentencing, District Judge King fixed bail for appeal at £1,000.

Carlsberg to buy Britvic for 1,315p per share Carlsberg will also buy out Marston's from brewing joint venture Danish brewer plans to create integrated beverage business in UK Shares in Carlsberg, Britvic, Marston's all rise July 8 (Reuters) - Carlsberg (CARLb.CO), opens new tab has agreed to buy British soft drinks maker Britvic (BVIC.L), opens new tab for 3.3 billion pounds ($4.23 billion), a move the Danish brewer said would forge a UK beverage "powerhouse" and that sent both companies' shares higher. Carlsberg clinched the takeover with a sweetened bid of 1,315 pence per share - comprising cash and a special dividend of 25 pence a share - after the British company rejected 1,250 pence per share last month. The acquisition will create value for shareholders, contribute to growth and forge a combined beer and soft drink company that is unique in the UK, CEO Jacob Aarup-Andersen told investors on a conference call. "With this transaction we are creating a UK powerhouse," he said. He brushed off concerns from some analysts about integration risks, saying Carlsberg has a strong track record of running beer and soft drink businesses in several markets. Soft drinks already make up 16% of Carlsberg's volumes. COST SAVINGS As drinkers in some markets ditch beer for spirits or cut back on drinking altogether, brewers have looked to broaden their portfolio into new categories like hard seltzer, canned cocktails and cider, as well as zero-alcohol brews. Britvic sells non-alcoholic drinks in Britain, Ireland, Brazil and other international markets such as France, the Middle East and Asia. Carlsberg said the deal will deliver a number of benefits, including cost and efficiency savings worth 100 million pounds ($128 million) over five years as it takes advantage of common procurement, production and distribution networks. It will also see Carlsberg take over Britvic's bottling agreement with PepsiCo (PEP.O), opens new tab. Carlsberg already bottles PepsiCo drinks in several markets and there is scope to add more geographies in future, Aarup-Andersen said. arlsberg halted share buy backs on Monday as a result of the deal. Chief financial officer Ulrica Fearn said these would resume once Carlsberg reaches its revised target for net debt of 2.5 times EBITDA, from 3.5 times currently - a goal it expects to meet in 2027. "Whilst this represents a shift in the strategy away from organic top- and bottom-line growth and consistent returns to shareholders, we view it as a relatively low risk transaction with attractive financials," Jefferies analysts said in a note. Carlsberg also said on Monday it will buy out UK pub group Marston's (MARS.L), opens new tab from a joint venture for 206 million pounds. That will give it full ownership of the newly formed Carlsberg Britvic after the deal. ($1 = 0.7805 pounds) Get the latest news and expert analysis about the state of the global economy with Reuters Econ World. Sign up here. Reporting by Stine Jacobsen, Yadarisa Shabong and Emma Rumney Editing by Sherry Jacob-Phillips, Rashmi Aich, David Goodman and David Evans

Incredible space photos like those from NASA don't look as stunning straight out of the telescope. They need significant processing, and a crucial part of that is sharpening. Coming to you from Unmesh Dinda with PiXimperfect, this fascinating video explores the APF-R plugin, developed by award-winning astrophotographer Christoph Kaltseis. APF-R stands for Absolute Point of Focus, and it's designed to enhance photo details without creating halos or artifacts. This technology has been used by space agencies with telescopes like the James Webb, and now, you can use it in Photoshop. The plugin allows for non-destructive editing, meaning you can adjust the radius and detail level without permanently altering your image. This feature is crucial for astrophotography, where preserving original details is vital. The video shows how APF-R compares to Photoshop's built-in sharpening tools. The plugin offers multiple rendering methods, each suited for different types of images. For instance, the "Center Weighted" method provides a balanced sharpening effect without making the image look overprocessed. Dinda explains how to fine-tune these settings to achieve the best results, making it clear why this plugin is a game-changer for photographers looking to enhance their images with precision. One notable feature of APF-R is its ability to work with different image types. The video demonstrates how the plugin enhances not just space photos but also landscapes and portraits. For portraits, APF-R can bring out skin textures and eye details without creating the unwanted halos that traditional sharpening methods often produce. Dinda also shows how to combine APF-R with other Photoshop tools, like Smart Sharpen, for even better results. This versatility makes APF-R a valuable addition to any photographer's toolkit. The plugin's cost is $50, which Dinda considers a bargain given its advanced capabilities. There's also a Creative Bundle subscription that includes APF-R and 20 other tools, offering great value for those looking to expand their editing options. Dinda provides discount codes in the video description, making this sophisticated tool more accessible. Check out the video above for the full rundown from Dinda.

An earthquake jolted New York City on Friday morning, followed by more than 10 aftershocks which shook New Jersey, sending tremors as far as Philadelphia to Boston and jolting buildings in Manhattan and throughout its five boroughs. The preliminary quake, measuring 4.8 magnitude, centered around Lebanon, New Jersey, approximately 60 kilometers from New York City, with a depth of about 5 kilometers. Following the earthquake, New York City mayor Eric Adams stated at a press conference that no injuries had been reported, but they would continue to monitor and inspect critical infrastructure. The densely populated New York City was caught off guard by the unusual event. Broadcaster CBS reported that New York had not experienced an earthquake of this magnitude since 1884. Residents in Brooklyn expressed their shock when experiencing tremors which shook the city. "At first, I thought it was just construction next door, but then I noticed the pictures on the wall had fallen," Jennifer Wu, a resident in New York, told the Global Times on Saturday. Video footage circulating online showed the Statue of Liberty and the New York City skyline trembling as the earthquake struck. An angle from directly above Lady Liberty caught Ellis Island shaking during the incident. "It is fine," New York's famous Empire State Building posted on social platform X after the earthquake. The United Nations headquarters located in New York was hosting a Security Council meeting on the Israeli-Palestinian issue, and diplomats present in the meeting felt the tremors, local media reported. According to the Weather Channel, residents in Baltimore, Philadelphia, New Jersey, Connecticut, Boston and other areas of the Northeast seaboard also reported shaking. Tremors lasting for several seconds were felt over 200 miles away near the Massachusetts-New Hampshire border. The New York mayor told the press that New Yorkers should go about their normal day, while the governor Kathy Hochul emphasized the seriousness of the situation. She initiated assessments for damage across the state and had discussions with New Jersey Governor Phil Murphy. The quake caused flight delays throughout the New York area, with temporary control measures put in place across New York's John F. Kennedy International Airport, Newark Liberty International Airport in Newark, New Jersey, and Baltimore-Washington's Thurgood Marshall International Airport, checking for damage to runways. Operations resumed around Friday noon, ABC reported.