A provocative new study reveals the complex effects of the space environment on human health, providing insight into potential damage to blood, cell structure and the immune system. The study focused on SpaceX's Inspiration4 mission, which successfully sent two men and two women into space in 2021 to orbit the Earth for three days and shed some light on the effects of space travel on the human body. The research data, derived directly from the Inspiration4 mission, shows that even a brief trip to space can significantly damage the human immune system, trigger an inflammatory response, and profoundly affect cell structure. In particular, space travel triggered unprecedented changes in cytokines that play a key role in immune response and muscle regulation but are not usually directly associated with inflammation. In particular, the study found a significant increase in muscle factors, which are physiological responses specific to skeletal muscle cells in microgravity, rather than a simple immune response. Although non-muscular tissues did not show changes in proteins associated with inflammation, specific leg muscles such as soleus and tibialis anterior muscles showed significant signs of metabolic activity, especially increased interleukin in the latter, further enhancing the activation of immune cells.

WASHINGTON, June 24 (Reuters) - Problems with Boeing's Starliner capsule, still docked at the International Space Station (ISS), have upended the original plans for its return of its two astronauts to Earth, as last-minute fixes and tests draw out a mission crucial to the future of Boeing's (BA.N), opens new tab space division. NASA has rescheduled the planned return three times, and now has no date set for it. Since its June 5 liftoff, the capsule has had five helium leaks, five maneuvering thrusters go dead and a propellant valve fail to close completely, prompting the crew in space and mission managers in Houston to spend more time than expected pursuing fixes mid-mission. Here is an explanation of potential paths forward for Starliner and its veteran NASA astronauts, Barry "Butch" Wilmore and Sunita "Suni" Williams. THE CURRENT SITUATION Starliner can stay docked at the ISS for up to 45 days, according to comments by NASA's commercial crew manager Steve Stich to reporters. But if absolutely necessary, such as if more problems arise that mission officials cannot fix in time, it could stay docked for up to 72 days, relying on various backup systems, according to a person familiar with flight planning. Internally at NASA, Starliner's latest targeted return date is July 6, according to this source, who spoke on condition of anonymity. Such a return date would mean that the mission, originally planned for eight days, instead would last a month. Starliner's expendable propulsion system is part of the craft's "service module." The current problems center on this system, which is needed to back the capsule away from the ISS and position it to dive through Earth's atmosphere. Many of Starliner's thrusters have overheated when fired, and the leaks of helium - used to pressurize the thrusters - appear to be connected to how frequently they are used, according to Stich.

McDonald's China, together with its four major suppliers announced the launch of an industrial park in Xiaogan city, Central China's Hubei Province on Wednesday, highlighting the importance of Chinese market in terms of supply chain for food business. With a combined investment of 1.5 billion yuan ($206 million), the park, named Hubei Smart Food Industrial Park, is a joint project with Bimbo QSR, XH Supply Chain, Tyson Foods Inc, and Zidan, according to information provided to the Global Times. The park is expected to produce 34,000 tons of meat products, 270 million buns, 30 million pastries, and 2 billion packaged products annually. It also features a 25,000-square-meter high-standard automated warehouse for frozen, refrigerated, and dry goods, reducing logistics time by 90 percent from manufacturing to arriving at the destination. Leveraging local geographical advantages, the park will become a supply hub for McDonald's in central and western China, enhancing supply efficiency and stability for its outlets there, the company said. "McDonald's has been deeply rooted in China for over 30 years, and the park is an echo of our long-term development in China," said Phyllis Cheung, CEO of McDonald's China. "Without any long-term strategy, we don't have any structural advantage in China," Cheung noted. The US food giant continues to expand its business map in China. As of the end of June in 2024, there were over 6,000 restaurants and over 200,000 employees in the market. China has become the second largest and fastest-growing market of McDonald's. In 2023, McDonald's China unveiled the ambition of operating 10,000 restaurants by 2028. To support this, McDonald's and its suppliers have invested over 12 billion yuan from between 2018 to 2023 to develop new production capacities and enhance supply chain sustainability. Observers said that the industrial park reflect foreign companies' confidence in operating in China as the country takes concrete measures in furthering reform and opening-up. China's foreign direct investment from January to May 2024 reached 412.51 billion yuan, with the number of newly-established foreign-backed companies reaching 21,764, rising by 17.4 percent year-on-year, data from China's Ministry of Commerce revealed. According to a recent survey by the American Chamber of Commerce in China, the majority of US companies saw improved profitability in China in 2023, and half of the survey participants put China as their first choice or within their top three investment destinations globally. Olaf Korzinovski, EVP of Volkswagen China, who is responsible for production and components, also shared his understanding of supply chains in China with the Global Times. Volkswagen has been operating in China for about 40 years. "In order to seize greater value for our customers," Volkswagen Group is stepping up pace of innovation in China, and systematically purshing forward the digitalization process, Korzinovski noted, adding the company is strengthening local capabilities with accelerated decision-making efficiency. Global Times

LONDON, July 9 (Reuters) - U.S.-based hedge fund Elliott Associates on Tuesday urged a London court to overturn a verdict supporting the London Metal Exchange's (LME) cancellation of nickel trades partly because the exchange failed to disclose documents. The LME annulled $12 billion in nickel trades in March 2022 when prices shot to records above $100,000 a metric ton in a few hours of chaotic trade. Elliott and market maker Jane Street Global Trading brought a case demanding a combined $472 million in compensation, alleging at a trial in June last year that the 146-year-old exchange had acted unlawfully. London's High Court ruled last November that the LME had the right to cancel the trades because of exceptional circumstances, and was not obligated to consult market players prior to its decision. Lawyers for Elliott told London's Court of Appeal that the LME belatedly released documents in May detailing its "Kill Switch" and "Trade Halt" internal procedures. It also newly disclosed an internal report that Elliott said detailed potential conflicts of interest at the exchange. "It was troubling that one gets disclosure out of the blue in the Court of Appeal for the first time," Elliott lawyer Monica Carss-Frisk told the court. Jane Street Global did not appeal the ruling. "If we had had them (documents) in the proceedings before the divisional court, we may well have sought permission to cross examine." LME lawyers said the new documents were not relevant. "The disclosed documents do not affect the reasoning of the divisional court or the merits of the arguments on appeal," the exchange said in documents prepared for the appeal hearing. "Elliott's appeal is largely a repetition of the arguments which were advanced, and rightly rejected." The LME said it had both the power and a duty to unwind the trades because a record $20 billion in margin calls could have led to at least seven clearing members defaulting, systemic risk and a potential "death spiral". Elliott said the ruling diluted protection provided by the Human Rights Act and also wrongly concluded the LME had the power to cancel the trades.

On July 8, local time, former British Prime Minister Sunak announced the appointment of the Conservative Party Shadow Cabinet, which is the first shadow cabinet of the Conservative Party in 14 years. Several former British cabinet members during Sunak's tenure as prime minister were appointed to the Conservative Party Shadow Cabinet, including James Cleverly as Shadow Home Secretary and Jeremy Hunt as Shadow Chancellor of the Exchequer. But former Foreign Secretary Cameron was not appointed as Shadow Foreign Secretary. In addition, the new leader of the Conservative Party will be elected as early as this week. On July 4, the UK held a parliamentary election. The counting results showed that the British Labour Party won more than half of the seats and won an overwhelming victory; the Conservative Party suffered a disastrous defeat, ending its 14-year continuous rule.