A provocative new study reveals the complex effects of the space environment on human health, providing insight into potential damage to blood, cell structure and the immune system. The study focused on SpaceX's Inspiration4 mission, which successfully sent two men and two women into space in 2021 to orbit the Earth for three days and shed some light on the effects of space travel on the human body. The research data, derived directly from the Inspiration4 mission, shows that even a brief trip to space can significantly damage the human immune system, trigger an inflammatory response, and profoundly affect cell structure. In particular, space travel triggered unprecedented changes in cytokines that play a key role in immune response and muscle regulation but are not usually directly associated with inflammation. In particular, the study found a significant increase in muscle factors, which are physiological responses specific to skeletal muscle cells in microgravity, rather than a simple immune response. Although non-muscular tissues did not show changes in proteins associated with inflammation, specific leg muscles such as soleus and tibialis anterior muscles showed significant signs of metabolic activity, especially increased interleukin in the latter, further enhancing the activation of immune cells.

The U.S. Navy's Pacific Fleet announced on Wednesday (May 22) that the 2024 Rim of the Pacific Exercise (RIMPAC 2024) is expected to take place on June 26, with 29 countries participating in and around the Hawaiian Islands, a larger lineup than the previous exercise in 2022. The Philippines, which has had multiple maritime conflicts with China recently, and Japan, which has tense diplomatic relations with China, will send troops to participate. China has been excluded from participating in the international military exercise since 2018, and its aggressive actions and reactions are causing tensions in the Pacific region to continue to rise. The biennial Rim of the Pacific military exercise is the world's largest international maritime exercise. The U.S. Navy said that the exercise will last until August 2, and it is expected to involve 29 countries, 40 surface ships, 3 submarines, 14 countries' army forces, more than 150 aircraft and more than 25,000 personnel. The U.S. Navy said that the theme of the 29th RIMPAC 2024 is "Partners: Integrated and Ready", emphasizing inclusiveness as the core, promoting multinational cooperation and trust, and using military interoperability to achieve their respective national goals to strengthen integrated and ready alliance partners. Its goal is to "enhance collective strength and promote a free and open Indo-Pacific region" through joint training and operations. The 29 countries participating in the exercise this year include Australia, Belgium, Brazil, Brunei, Canada, Chile, Colombia, Denmark, Ecuador, France, Germany, India, Indonesia, Israel, Italy, Japan, Malaysia, Mexico, the Netherlands, New Zealand, Peru, South Korea, the Philippines, Singapore, Sri Lanka, Thailand, Tonga, the United Kingdom and the United States. Compared with the 28th RIMPAC held in 2022, which involved 26 countries, 38 surface ships, 4 submarines, 9 countries' army forces, more than 170 aircraft, and about 25,000 officers and soldiers, the number of countries, ships and army forces participating in this exercise has increased. The countries participating in this year's RIMPAC military exercise include all members of the Quadrilateral Security Dialogue (QUAD) between the United States, Japan, India and Australia, and the Australia-UK-US Trilateral Security Partnership (AUKUS), as in the previous exercise. In addition, countries surrounding the South China Sea and the South Pacific island nation of Tonga are also participating. Many analysts believe that the military exercise itself is sending a message to China: China's expansion in the Western Pacific region will be blocked and defeated. The United States invited China to participate in the RIMPAC military exercise twice in 2014 and 2016. In 2018, due to China's expansion in the South China Sea, the United States withdrew its invitation to China. In addition, despite Taiwan's repeated willingness to participate, Taiwan is still not included in the 29 countries participating in this year's RIMPAC military exercise. Analysts pointed out that the US-led RIMPAC military exercise is intended to unite allies to militarily intimidate China. If Taiwan is invited to join, it will be too provocative to China, which will not only aggravate the tension between the United States and China, but also embarrass some allies. The U.S. Navy said the commander of the U.S. Third Fleet will serve as the commander of the joint task force for the exercise, while Chilean Navy Commodore Alberto Guerrero will serve as deputy commander of the joint task force, which is a first in the history of the RIMPAC military exercise. In addition, Japan Maritime Self-Defense Force Rear Admiral Kazushi Yokota will also serve as deputy commander. Other key leaders of the multinational force exercise include Canadian Commodore Kristjan Monaghan, who will command the maritime forces, and Australian Air Force Commodore Louise Desjardins, who will command the air forces. According to the U.S. Stars and Stripes, Vice Admiral Michael Boyle is currently the commander of the U.S. Third Fleet. Vice Admiral John Wade has been nominated to replace Boyle. The U.S. Navy press release said the exercise will enhance the ability of international joint forces to "deter and defeat aggression by major powers in all domains and conflict levels," but did not provide specific information on which exercises will be held this summer. Previous RIMPAC training exercises have included sinking ships at sea with missiles, amphibious landings and the first landing of a Marine Corps Osprey aircraft on an Australian ship.

A look at the day ahead in U.S. and global markets from Mike Dolan After an intense month focused on election risk around the world, markets quickly switched back to the more prosaic matter of the cost of money - and whether disinflation is resuming to the extent it allows borrowing costs to finally fall. Thursday's U.S. consumer price update for June is the key moment of the week for many investors - with the headline rate expected to have fallen two tenths of a percentage point to 3.1% but with 'core' rates still stuck at 3.4%. With Federal Reserve chair Jerome Powell starting his two-pronged semi-annual congressional testimony later on Tuesday, the consensus CPI forecast probably reflects what the central bank thinks of the situation right now - encouraging but not there yet. But as the U.S. unemployment rate is now back above 4.0% for the first time since late 2021, markets may look for a more nuanced approach from the Fed chair that sees it increasingly wary of a sudden weakening of the labor market as real time quarterly GDP estimates ebb again to about 1.5%. There were some other reasons for Fed optimism in the lead up to the testimony. The path U.S. inflation is expected to follow over coming years generally softened in June, amid retreating projections of price increases for a wide array of consumer goods and services, a New York Fed survey showed on Monday. Inflation a year from now was seen at 3% as of June - down from the expected rise of 3.2% in May - and five-year expectations fell to 2.8% from 3%. Crude oil prices are better behaved this week, too, falling more than 3% from the 10-week highs hit late last week and halving the annual oil price gain to 10%. The losses on Tuesday came after a hurricane that hit a key U.S. oil-producing hub in Texas caused less damage than many in markets had expected - easing concerns over supply disruption. Before Powell starts speaking later, there will also be an update on U.S. small business confidence for last month.

JOHANNESBURG, July 9 (Reuters) - The South African rand was little changed in early trade on Tuesday, as markets awaited the Federal Reserve chair's testimony in Washington and U.S. June inflation data for clues on the country's future interest rate path. At 0644 GMT, the rand traded at 18.1300 against the dollar , near its previous close of 18.1175. "The rand has opened marginally softer at 18.13 this morning, and we expect trading to remain range-bound in the short term," said Andre Cilliers, currency strategist at TreasuryONE. Markets will listen to the tone of Fed Chair Jerome Powell's testimony in Washington on Tuesday and Wednesday and look to June inflation data out of the U.S. later this week for hints on the future interest rate path in the world's biggest economy. "Analysts will be gauging the Fed's response to the recent softer U.S. economic and labour data, with markets already starting to price in two rate cuts this year," Cilliers added. The risk-sensitive rand often takes cues from global drivers like U.S. economic policy in the absence of major local factors. South Africa's benchmark 2030 government bond was slightly stronger in early deals, with the yield down 1 basis point at 9.74%.

The world's deepest diving pool, Deepspot, opened this weekend near the Polish capital Warsaw. The 45.5-meter pool contains artificial underwater caves, Mayan ruins and a small shipwreck for scuba divers and free divers to explore. Deepspot can hold 8,000 cubic meters of water, more than 20 times the capacity of a normal 25-meter swimming pool. Unlike ordinary swimming pools, Deepspot can still open despite Poland's COVID-19 epidemic prevention restrictions because it is a training center that provides courses. The operator also plans to open a hotel where guests can observe divers at a depth of 5 meters from their rooms. "This is the deepest diving pool in the world," Michael Braszczynski, 47, Deepspot's director and a diving enthusiast, told AFP at the opening yesterday. The current Guinness World Record holder is a 42-meter-deep pool in Montegrotto Terme, Italy. The 50-meter-deep Blue Abyss pool in the UK is scheduled to open in 2021. On the first day of Deepspot's opening, about a dozen people visited, including eight experienced divers who wanted to pass the instructor exam. "There are no spectacular fish or coral reefs here, so it can't replace the ocean, but it is certainly a good place to learn and train safe open water diving," said 39-year-old diving instructor Przemyslaw Kacprzak. "And it's fun! It's like a kindergarten for divers."